Hormones
SHBG
LOINC 13967-5 · nmol/L
What it is
SHBG (sex hormone-binding globulin) is a protein that binds sex hormones, especially testosterone, controlling how much is freely available.
Why it matters
It helps interpret testosterone and estrogen levels, since it changes how much hormone is active.
What high values can mean
A higher value means more hormone is bound and less is freely available; it can rise with certain conditions or medications.
What low values can mean
A lower value means more free hormone and can occur with insulin resistance, obesity or some hormonal states.
How to improve it
SHBG often shifts with metabolic health; weight management and improving insulin sensitivity can raise a low SHBG.
Food & lifestyle
A balanced diet, activity and a healthy weight support metabolic health, which influences SHBG.
Preparing for the test
A blood test; fasting may be requested — follow your lab's instructions.
When to talk to a doctor
SHBG is interpreted by a doctor together with testosterone to estimate active hormone.
Related markers
Sources
- Testing.com (AACC)
- MedlinePlus (NIH)
Content reviewed on June 26, 2026
Medical disclaimer
This content is for educational purposes only. It is not medical advice and does not diagnose, treat, or prevent any condition. Reference ranges vary between laboratories — always use the range printed on your report and discuss your results with a healthcare professional.
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