Blood count
Haptoglobin
LOINC 4542-7 · mg/dL
Ranges
Reference range: 30–200 mg/dL
What it is
Haptoglobin is a protein made by the liver that binds free hemoglobin released when red blood cells break down.
Why it matters
Because it is consumed when red cells are destroyed, a low haptoglobin is a useful marker of hemolysis (red-cell breakdown).
What high values can mean
A higher value can occur with inflammation or infection, since haptoglobin rises as an acute-phase protein.
What low values can mean
A lower value can indicate that red cells are breaking down faster than usual, or reduced production by the liver.
How to improve it
Treatment targets the underlying cause; haptoglobin itself is not changed by lifestyle.
Food & lifestyle
No specific diet changes haptoglobin; supporting general liver health is sensible overall.
Preparing for the test
A simple blood test; fasting is not usually required — follow your lab's instructions.
When to talk to a doctor
Discuss a low haptoglobin with a doctor, particularly with tiredness, pale skin or jaundice.
Related markers
Sources
- MedlinePlus (NIH)
- Testing.com (AACC)
Content reviewed on June 26, 2026
Medical disclaimer
This content is for educational purposes only. It is not medical advice and does not diagnose, treat, or prevent any condition. Reference ranges vary between laboratories — always use the range printed on your report and discuss your results with a healthcare professional.
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